First case of proven invasive pulmonary infection due to Trichoderma longibrachiatum in a neutropenic patient with acute leukemia.

Date publication

décembre 2018

Journal

Journal de mycologie medicale

Auteurs

Membres identifiés du Cancéropôle Est :
Dr CAILLOT Denis , Dr CHRETIEN Marie-Lorraine

Tous les auteurs :
Sautour M, Chrétien ML, Valot S, Lafon I, Basmaciyan L, Legouge C, Verrier T, Gonssaud B, Abou-Hanna H, Dalle F, Caillot D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30477694

Résumé

Trichoderma species are saprophytic filamentous fungi that can be found all over the word. These fungi show increasing medical importance as opportunistic human pathogens, particularly in immunocompromised patients. Invasive infections due to Trichoderma are rare and definitive diagnosis is complex to achieve because of the lack of specific diagnosis tools. We report in this work the first proven case of invasive pulmonary infection due to T. longibrachiatum in a 69-year-old white male with hematologic malignancy. The patient was successfully treated initially with voriconazole alone followed by a combination of voriconazole and caspofungine.

Mots clés

(1–3)-β-D-glucan, Caspofungin-voriconazole combination therapy, Invasive pulmonary infection, Serum Aspergillus galactomannan, Trichoderma longibrachiatum

Référence

J Mycol Med. 2018 Dec;28(4):659-662