Fiche publication
Date publication
décembre 2018
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GARBAR Christian
,
Pr MERROUCHE Yacine
,
Pr ANTONICELLI Franck
,
Pr BENSUSSAN Armand
Tous les auteurs :
Fabre JAS, Giustinniani J, Garbar C, Merrouche Y, Antonicelli F, Bensussan A
Lien Pubmed
Résumé
Breast cancer (BC) is the most common cancer in women worldwide and remains a major cause of mortality with an expected 137,000 death this year in Europe. Standard management of metastatic BC comprises hormonotherapy, chemotherapy, and targeted therapies. Cyclin dependent kinase (CDK) and mammalian target of rapamycin (mTOR) inhibitors have recently proved their efficiency in hormonal receptor expressing BC. Checkpoint proteins inhibition is being evaluated in phase 3 studies. Since inflammation is constantly present in cancers, research teams have focused their attention on the interleukin-17 (IL-17) family of proinflammatory cytokines. Preclinical experiments have reported both pro and antitumor effects depending on the conditions. In the present article, we review the accumulating evidences about the roles of IL-17 in BC and discuss whether this family of cytokines could be a new target in anticancer treatments.
Mots clés
antitumor effects, breast cancer, immunotherapy, interleukin-17, new target, protumor effects
Référence
Int J Mol Sci. 2018 Dec 4;19(12):
