Regenerative Capacity of Endogenous Factor: Growth Differentiation Factor 11; a New Approach of the Management of Age-Related Cardiovascular Events.

Fiche publication

Date publication

décembre 2018

Journal

International journal of molecular sciences

Auteurs

Membres identifiés du Cancéropôle Est :
Pr COTTIN Yves , Pr VERGELY Catherine

Tous les auteurs :
Rochette L, Meloux A, Rigal E, Zeller M, Cottin Y, Malka G, Vergely C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30545044

Résumé

Aging is a complicated pathophysiological process accompanied by a wide array of biological adaptations. The physiological deterioration correlates with the reduced regenerative capacity of tissues. The rejuvenation of tissue regeneration in aging organisms has also been observed after heterochronic parabiosis. With this model, it has been shown that exposure to young blood can rejuvenate the regenerative capacity of peripheral tissues and brain in aged animals. An endogenous compound called growth differentiation factor 11 (GDF11) is a circulating negative regulator of cardiac hypertrophy, suggesting that raising GDF11 levels could potentially treat or prevent cardiac diseases. The protein GDF11 is found in humans as well as animals. The existence of endogenous regulators of regenerative capacity, such as GDF11, in peripheral tissues and brain has now been demonstrated. It will be important to investigate the mechanisms with therapeutic promise that induce the regenerative effects of GDF11 for a variety of age-related diseases.