MITF-high and MITF-low cells and a novel subpopulation expressing genes of both cell states contribute to intra and inter-tumoral heterogeneity of primary melanoma.

Date publication

août 2017

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DAVIDSON Irwin , Pr LIPSKER Dan , Mme THIBAULT-CARPENTIER Christelle

Tous les auteurs :
Ennen M, Keime C, Gambi G, Kieny A, Coassolo S, Thibault-Carpentier C, Margerin-Schaller F, Davidson G, Vagne C, Lipsker D, Davidson I

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28855355

Résumé

Understanding tumour heterogeneity is an important challenge in current cancer research. Transcription and epigenetic profiling of cultured melanoma cells have defined at least two distinct cell phenotypes characterised by distinctive gene expression signatures associated with high or low/absent expression of Microphthalmia-associated transcription factor (MITF). Nevertheless, heterogeneity of cell populations and gene expression in primary human tumours is much less well characterised.

Mots clés

Adult, Aged, 80 and over, Biomarkers, Tumor, Cell Line, Tumor, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genetic Heterogeneity, Humans, Male, Melanoma, genetics, Microphthalmia-Associated Transcription Factor, genetics, Mutation, Single-Cell Analysis

Référence

Clin. Cancer Res.. 2017 Aug;: