Optimization of liposomal indocyanine green for imaging of the urinary pathways and a proof of concept in a pig model.

Date publication

août 2017

Journal

Surgical endoscopy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MARESCAUX Jacques

Tous les auteurs :
Friedman-Levi Y, Larush L, Diana M, Marchegiani F, Marescaux J, Goder N, Lahat G, Klausner J, Eyal S, Magdassi S, Nizri E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28779247

Résumé

Iatrogenic ureteral injury is an increasing concern in the laparoscopic era, affecting both patient morbidity and costs. Current techniques enabling intraoperative ureteral identification require invasive procedures or radiations. Our aim was to develop a real-time, non-invasive, radiation-free method to visualize ureters, based on near-infrared (NIR) imaging. For this purpose, we interfered with the biliary excretion pathway of the indocyanine green (ICG) fluorophore by loading it into liposomes, enabling renal excretion. In this work, we studied various parameters influencing ureteral imaging.

Mots clés

Indocyanine green, Liposomes, Minimal invasive surgery, Ureteral injury

Référence

Surg Endosc. 2017 Aug;: