Fiche publication
Date publication
décembre 2018
Journal
Drug discovery today. Technologies
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WAGNER Alain
,
Dr CHAUBET Guilhem
Tous les auteurs :
Chaubet G, Thoreau F, Wagner A
Lien Pubmed
Résumé
This review will discuss recent development in the bioconjugation of lysine residues on antibodies. As several chemoselective reagents have already been developed for modifying amine groups, recent strategies now tend to aim at being site-specific. Four general methods have been listed: kinetically controlled, template-directed or enzymatic strategies as well as the use of chemically programmed antibodies.
Mots clés
Humans, Immunoconjugates, chemistry, Lysine, chemistry, Structure-Activity Relationship
Référence
Drug Discov Today Technol. 2018 Dec;30:21-26
