[(11)C]PF-3274167 as a PET radiotracer of oxytocin receptors: Radiosynthesis and evaluation in rat brain.

Fiche publication

Date publication

août 2017

Journal

Nuclear medicine and biology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr HIBERT Marcel

Tous les auteurs :
Vidal B, Karpenko IA, Liger F, Fieux S, Bouillot C, Billard T, Hibert M, Zimmer L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28917111

Résumé

Oxytocin plays a major role in the regulation of social interactions in mammals by interacting with the oxytocin receptor (OTR) expressed in the brain. Furthermore, the oxytocin system appears as a possible therapeutic target in autism spectrum disorders and other psychiatric troubles, justifying current pharmacological researches. Since no specific PET radioligand is currently available to image OTR in the brain, the aim of this study was to radiolabel the specific OTR antagonist PF-3274167 and to evaluate [(11)C]PF-3274167 as a potential PET tracer for OTR in rat brains.