Fiche publication
Date publication
janvier 2019
Journal
Materials science & engineering. C, Materials for biological applications
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie
,
Dr KERDJOUDJ Halima
Tous les auteurs :
Akilal N, Lemaire F, Bercu NB, Sayen S, Gangloff SC, Khelfaoui Y, Rammal H, Kerdjoudj H
Lien Pubmed
Résumé
Carbonate apatites are sought as a bone substitute due to their biocompatibility and excellent resorbability. The present study deals with Cowrie's shell derived powder (CSDP) as natural biomaterial for bone regenerative medicine. Structural and physicochemical analysis showed that Cowrie's shells, presenting brick and mortar microstructures, were mainly composed of aragonite crystals, which were converted into poorly crystalline B-type carbonate apatite once soaked, at 37 °C, in simulated body fluid for 7 days, reflecting bioactive features. Cytotoxic assays showed that CSDP boosted human stem cell proliferation over the study time compared to nacre derived powder (NDP), used as positive control. Human stem cells adopted a flattened morphology and established physical contact with CSDP, signature of a good biocompatibility. Thus, these results suggested that CSDP presents a great interest for bone regenerative medicine, and could be a useful and versatile carrier/scaffold for bone tissue engineering or a raw material for 3D printed orthopedic devices.
Mots clés
Aragonite, Biocompatibility, Biomaterials, Carbonate apatite, Cowries
Référence
Mater Sci Eng C Mater Biol Appl. 2019 Jan 1;94:894-900
