Fiche publication
Date publication
décembre 2018
Journal
Bulletin du cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François
Tous les auteurs :
Ghiringhelli F
Lien Pubmed
Résumé
Recent advances in immuno-oncology with the development of anti-PD1/PD-L1 antibodies are revolutionizing oncological management. Immuno-oncology I currently developing in most histological types of cancer. However, the rate of success of anti-PD1/PD-L1 antibodies in monotherapy is limited by a limited to a subpopulation of patients accounting for about 25-30 % of patients in most indications. The development of new strategies is based on this observation with the aim to predict response or enhancing response rate. Thus, we note the development of different strategies aimed at better selecting patients or combining inhibitory checkpoints with other therapies in order to increase their effectiveness. This review will study therapeutic test strategies to validate these new associations.
Mots clés
Biomarkers, Biomarqueurs, Checkpoint inhibitors, Chimio-immunothérapie, Immunotherapy, Immunothérapie
Référence
Bull Cancer. 2018 Dec;105 Suppl 1:S101-S112
