Chemical constituents of Genista numidica Spach aerial parts and their antimicrobial, antioxidant and antityrosinase activities.

Fiche publication

Date publication

février 2018

Journal

Natural product research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie

Tous les auteurs :
Boutaghane N, Alabdul Magid A, Abedini A, Cafolla A, Djeghim H, Gangloff SC, Voutquenne-Nazabadioko L, Kabouche Z

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29448823

Résumé

A previously undescribed triterpenoid saponin, 3-O-[α-l-rhamnopyranosyl-(1→2)-{β-d-glucopyranosyl-(1→6)-}β-d-galactopyranosyl-(1→2)-β-d-glucuronopyranosyl]-sophoradiol (1), in addition to twenty-nine known constituents (2-30) were isolated from the aerial parts of Genista numidica Spach. Structures elucidation was performed by comprehensive 1D- and 2D-NMR analyses and HRESIMS. The extracts, fractions and isolated compounds were evaluated for their antibacterial, antioxidant and tyrosinase inhibitory activities. The experimental findings indicated that genistin (16), isosalipurpol (27), and koaburaside (29) have moderate to low antibacterial activity against E. faecalis, S. aureus, S. epidermidis and P. aeruginosa bacteria with MICs ranging from 31.2 to 125 μg/mL. Compounds 19 and 27 exhibited a good antiradical activity potential (IC 11.8 and 11.1 μg/mL, respectively). Only compounds 23, 27 and 28 exhibited low inhibitory effect against mushroom tyrosinase (IC from 90.2 to 225.6 μg/mL).