Fiche publication
Date publication
septembre 2017
Journal
Phytochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie
Tous les auteurs :
Muhammad D, Lalun N, Bobichon H, Le Magrex Debar E, Gangloff SC, Nour M, Voutquenne-Nazabadioko L
Lien Pubmed
Résumé
Six previously undescribed triterpenoid saponins and two previously undescribed norlupane triterpenes were isolated with five known saponins, three known lupane derivatives, 17,20-didehydro-20-deoxyjujubogenin, rutin, (±) 3α-O-β-d-glucopyranosyl-lyoniresinol, (±) 4-O-β-d-glucopyranosyl-maesopsin, three phenol glycosides, and uridine from the stems and bark of Jaffrea xerocarpa (Baill.) H. C. Hopkins & Pillon (= Basionym Alphitonia xerocarpus Baill.) (Rhamnaceae), an endemic tree of New Caledonia. The chemical structures of the purified compounds were identified by nuclear magnetic resonance and mass spectrometry. The isolated compounds were tested for their antioxidant, antityrosinase, antibacterial and cytotoxic activities. The aqueous methanol extract showed antioxidant activity (DPPH assay) due to the presence of rutin and other phenolic compounds. Three lupane triterpenes showed good cytotoxic activities against KB cells line (IC from 7.7 to 8.5 μM). The previously undescribed 2α-formyl-A(1)norlup-20(29)-en-28-oic acid showed antibacterial activity against Staphylococcus aureus and Enterococcus faecalis with both MIC values of 4 μg/mL.
Mots clés
Anti-Bacterial Agents, chemistry, Antioxidants, chemistry, Enterococcus faecalis, drug effects, Humans, KB Cells, Microbial Sensitivity Tests, Molecular Structure, Plant Bark, chemistry, Plant Stems, chemistry, Rhamnaceae, chemistry, Saponins, chemistry, Staphylococcus aureus, drug effects, Triterpenes, chemistry
Référence
Phytochemistry. 2017 Sep;141:121-130
