Modeling human disease in rodents by CRISPR/Cas9 genome editing.

Date publication

juillet 2017

Journal

Mammalian genome : official journal of the International Mammalian Genome Society

Auteurs

Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann

Tous les auteurs :
Birling MC, Herault Y, Pavlovic G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28677007

Résumé

Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.

Mots clés

Animals, Animals, Genetically Modified, CRISPR-Cas Systems, Disease Models, Animal, Gene Editing, Genetic Association Studies, methods, Genetic Predisposition to Disease, Genetic Therapy, methods, Genetic Variation, Genomics, methods, Humans, Mice, Models, Biological, Multifactorial Inheritance, Open Reading Frames, Precision Medicine, RNA, Untranslated, Regulatory Sequences, Ribonucleic Acid

Référence

Mamm. Genome. 2017 Jul;: