A promising family of fluorescent water-soluble aza-BODIPY dyes for in vivo molecular imaging.

Date publication

janvier 2019

Journal

Bioconjugate chemistry

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BETTAIEB Ali , Pr PAUL Catherine , Pr DENAT Franck , Dr COLLIN Bertrand , Dr BELLAYE Pierre-Simon

Tous les auteurs :
Pliquett J, Dubois A, Racoeur C, Mabrouk N, Amor S, Lescure R, Bettaieb A, Collin B, Bernhard C, Denat F, Bellaye PS, Paul C, Bodio E, Goze C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30615430

Résumé

A new family of water-soluble and bioconjugatable aza-BODIPY fluorophores was designed and synthesized using a boron- functionalization strategy. These dissymmetric bis-ammonium aza-BODIPY dyes present optimal properties for a fluorescent probe, i.e. they are highly water-soluble, very stable in physiological medium, they do not aggregate in PBS, possess high quantum yield and finally they can be easily bioconjugated to antibodies. Preliminary in vitro and in vivo studies were per-formed for one of these fluorophores to image PD-L1 (Programmed Death-Ligand 1), highlighting the high potential of these new probes for future in vivo optical imaging studies.

Référence

Bioconjug. Chem.. 2019 Jan 7;: