Fiche publication
Date publication
juin 2017
Journal
Histopathology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MALOUF Gabriel
Tous les auteurs :
Classe M, Malouf GG, Su X, Yao H, Thompson EJ, Doss DJ, Grégoire V, Lenobin J, Fantoni JC, Sudour-Bonnange H, Khayat D, Aubert S, Tannir NM, Leroy X
Lien Pubmed
Résumé
Translocation renal cell carcinoma (tRCC) is a rare subtype of kidney tumour characterized by translocations involving the transcription factor TFE3 or TFEB. tRCC was introduced into the World Health Organization classification in 2004, but much is still unknown about the natural history, clinicopathological features and outcomes of the disease. The aim of this study was to describe the landscape of fusion transcript in a large single-institution series of fluorescence in-situ hybridization (FISH)-confirmed tRCCs and then to compare it to morphological and clinical data.
Mots clés
Adolescent, Adult, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, genetics, Carcinoma, Renal Cell, epidemiology, Carrier Proteins, genetics, Female, Humans, Incidence, Kidney Neoplasms, epidemiology, Male, Middle Aged, Oncogene Proteins, Fusion, genetics, Young Adult
Référence
Histopathology. 2017 Jun;70(7):1089-1097
