Fiche publication
Date publication
juin 2017
Journal
Nature communications
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann
,
Dr SORG Tania
Tous les auteurs :
Karp NA, Mason J, Beaudet AL, Benjamini Y, Bower L, Braun RE, Brown SDM, Chesler EJ, Dickinson ME, Flenniken AM, Fuchs H, Angelis MH, Gao X, Guo S, Greenaway S, Heller R, Herault Y, Justice MJ, Kurbatova N, Lelliott CJ, Lloyd KCK, Mallon AM, Mank JE, Masuya H, McKerlie C, Meehan TF, Mott RF, Murray SA, Parkinson H, Ramirez-Solis R, Santos L, Seavitt JR, Smedley D, Sorg T, Speak AO, Steel KP, Svenson KL, ,Wakana S, West D, Wells S, Westerberg H, Yaacoby S, White JK
Lien Pubmed
Résumé
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
Mots clés
Animals, Body Weight, Female, Genes, Modifier, Genotype, Mammals, physiology, Mice, Phenotype, Quantitative Trait, Heritable, Sex Characteristics
Référence
Nat Commun. 2017 Jun;8:15475
