Fiche publication
Date publication
juin 2017
Journal
European journal of cancer (Oxford, England : 1990)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr JUNG Alain
Tous les auteurs :
Mirghani H, Jung AC, Fakhry C
Lien Pubmed
Résumé
Human papillomavirus (HPV)-driven oropharyngeal cancers (OPCs) represent an increasing proportion of head and neck cancers that could become, in the next few decades, a public health problem in certain western countries. This significant epidemiological change strongly calls for preventive measures. Prophylactic HPV vaccination and screening programmes for early identification and treatment of premalignant lesions are currently being used to reduce the incidence of uterine cervical cancer, which is the paradigm of HPV-driven malignancy. These strategies have proven to be efficient as the incidence of cervical cancer has dramatically dropped since the 1960s in most countries where they are properly applied. The success of cervical cancer prevention encourages the development of similar approaches to prevent HPV-driven OPCs. However, a number of important limitations impede their application to HPV-driven OPCs, and the development of innovative and specific strategies dedicated to this disease are urgently needed. This article provides an overview on primary, secondary and tertiary prevention of HPV-driven OPC and discusses some directions for future research.
Mots clés
Adolescent, Adult, Aged, Biomarkers, Tumor, metabolism, DNA, Viral, metabolism, Early Detection of Cancer, methods, Female, Head and Neck Neoplasms, prevention & control, Humans, Male, Middle Aged, Papillomaviridae, genetics, Papillomavirus Infections, prevention & control, Papillomavirus Vaccines, Primary Prevention, methods, Risk Assessment, Secondary Prevention, methods, Tertiary Prevention, methods, Uterine Cervical Neoplasms, prevention & control, Vaccination, statistics & numerical data, Young Adult
Référence
Eur. J. Cancer. 2017 06;78:105-115
