Fiche publication
Date publication
mai 2017
Journal
Journal of hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas
Tous les auteurs :
Farquhar MJ, Humphreys IS, Rudge SA, Wilson GK, Bhattacharya B, Ciaccia M, Hu K, Zhang Q, Mailly L, Reynolds GM, Ashcroft M, Balfe P, Baumert TF, Roessler S, Wakelam MJO, McKeating JA
Lien Pubmed
Résumé
Chronic hepatitis C is a global health problem with an estimated 170 million hepatitis C virus (HCV) infected individuals at risk of progressive liver disease and hepatocellular carcinoma (HCC). Autotaxin (ATX, gene name: ENPP2) is a phospholipase with diverse roles in the physiological and pathological processes including inflammation and oncogenesis. Clinical studies have reported increased ATX expression in chronic hepatitis C, however, the pathways regulating ATX and its role in the viral life cycle are not well understood.
Mots clés
Animals, Cell Line, Hepacivirus, physiology, Hepatitis C, Chronic, complications, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, physiology, Liver Neoplasms, etiology, Mice, Phosphoric Diester Hydrolases, genetics, Promoter Regions, Genetic, RNA, Messenger, analysis, Receptors, Lysophosphatidic Acid, physiology, Signal Transduction, Virus Replication
Référence
J. Hepatol.. 2017 05;66(5):919-929
