Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis.

Fiche publication

Date publication

janvier 2019

Journal

Arthritis research & therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe

Tous les auteurs :
Trellu S, Courties A, Jaisson S, Gorisse L, Gillery P, Kerdine-Römer S, Vaamonde-Garcia C, Houard X, Ekhirch FP, Sautet A, Friguet B, Jacques C, Berenbaum F, Sellam J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30635030

Résumé

Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-lysine (CML). We aimed to investigate the expression of several AGEs and Glo-1 in human OA cartilage and to study chondrocytic Glo-1 regulation by inflammation, mediated by interleukin (IL)-1β.