Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Date publication

août 2014

Journal

Annals of oncology : official journal of the European Society for Medical Oncology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr COTTET Vanessa

Tous les auteurs :
Nitter M, Norgård B, de Vogel S, Eussen SJ, Meyer K, Ulvik A, Ueland PM, Nygård O, Vollset SE, Bjørge T, Tjønneland A, Hansen L, Boutron-Ruault M, Racine A, Cottet V, Kaaks R, Kühn T, Trichopoulou A, Bamia C, Naska A, Grioni S, Palli D, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, van Kranen H, Peeters PH, Weiderpass E, Dorronsoro M, Jakszyn P, Sánchez M, Argüelles M, Huerta JM, Barricarte A, Johansson M, Ljuslinder I, Khaw K, Wareham N, Freisling H, Duarte-Salles T, Stepien M, Gunter MJ, Riboli E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/24827130

Résumé

Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve as alternative methyl group donors when folate status is low.

Mots clés

Aged, Betaine, blood, Case-Control Studies, Choline, blood, Colorectal Neoplasms, blood, Europe, epidemiology, Female, Humans, Male, Methionine, blood, Middle Aged, Nutritional Status, physiology, Prospective Studies, Risk Factors, Sarcosine, analogs & derivatives

Référence

Ann. Oncol.. 2014 Aug;25(8):1609-15