Fiche publication
Date publication
novembre 2009
Journal
American journal of epidemiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr COTTET Vanessa
Tous les auteurs :
Cottet V, Touvier M, Fournier A, Touillaud MS, Lafay L, Clavel-Chapelon F, Boutron-Ruault MC
Lien Pubmed
Résumé
Since evidence relating diet to breast cancer risk is not sufficiently consistent to elaborate preventive proposals, the authors examined the association between dietary patterns and breast cancer risk in a large French cohort study. The analyses included 2,381 postmenopausal invasive breast cancer cases diagnosed during a median 9.7-year follow-up period (1993-2005) among 65,374 women from the E3N-EPIC cohort. Scores for dietary patterns were obtained by factor analysis, and breast cancer hazard ratios were estimated by Cox proportional hazards regression for the highest quartile of dietary pattern score versus the lowest. Two dietary patterns were identified: "alcohol/Western" (essentially meat products, French fries, appetizers, rice/pasta, potatoes, pulses, pizza/pies, canned fish, eggs, alcoholic beverages, cakes, mayonnaise, and butter/cream) and "healthy/Mediterranean" (essentially vegetables, fruits, seafood, olive oil, and sunflower oil). The first pattern was positively associated with breast cancer risk (hazard ratio = 1.20, 95% confidence interval (CI): 1.03, 1.38; P = 0.007 for linear trend), especially when tumors were estrogen receptor-positive/progesterone receptor-positive. The "healthy/Mediterranean" pattern was negatively associated with breast cancer risk (hazard ratio = 0.85, 95% CI: 0.75, 0.95; P = 0.003 for linear trend), especially when tumors were estrogen receptor-positive/progesterone receptor-negative. Adherence to a diet comprising mostly fruits, vegetables, fish, and olive/sunflower oil, along with avoidance of Western-type foods, may contribute to a substantial reduction in postmenopausal breast cancer risk.
Mots clés
Aged, Aged, 80 and over, Breast Neoplasms, epidemiology, Cohort Studies, Confidence Intervals, Diet, Factor Analysis, Statistical, Female, France, epidemiology, Humans, Life Style, Middle Aged, Nutritional Status, Postmenopause, Proportional Hazards Models, Prospective Studies, Qualitative Research, Receptors, Estrogen, Risk Assessment, Risk Factors, Surveys and Questionnaires
Référence
Am. J. Epidemiol.. 2009 Nov 15;170(10):1257-67
