Fiche publication
Date publication
janvier 2004
Journal
Nutrition and cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr COTTET Vanessa
Tous les auteurs :
Senesse P, Meance S, Cottet V, Faivre J, Boutron-Ruault MC
Lien Pubmed
Résumé
Several hypotheses have been proposed for colorectal carcinogenesis, including formation of free radicals. A case-control study compared nutrient intake in 171 colorectal cancer cases versus 309 general population controls, using a detailed face-to-face food history questionnaire. A food composition table enabled us to determine the mean composition of the diet in macro- and micronutrients. Dietary intakes were separately categorized into quartiles by gender. Logistic regression models were adjusted for age, sex, energy, exercise, and body mass index. High energy, copper, iron, and vitamin E intakes were associated with an overall increased risk of colorectal cancer. The odds ratios associated with the fourth quartile of intake were 2.3 (95% confidence interval, 1.3-4.0), 2.4 (1.3-4.6), 2.2 (1.1-4.7), and 1.8 (1.0-3.4) for energy, copper, iron, and vitamin E, respectively. There were no significant associations with dietary fiber, folate, calcium, or antioxidant vitamins other than vitamin E. These findings regarding iron and copper suggest that free radicals play an important role in colorectal carcinogenesis, while the findings regarding vitamin E are so far unexplained.
Mots clés
Adult, Aged, Antioxidants, administration & dosage, Case-Control Studies, Colorectal Neoplasms, epidemiology, Copper, administration & dosage, Energy Intake, Feeding Behavior, Female, France, epidemiology, Humans, Iron, Dietary, administration & dosage, Logistic Models, Male, Middle Aged, Odds Ratio, Surveys and Questionnaires, Vitamin E, administration & dosage
Référence
Nutr Cancer. 2004 ;49(1):66-71
