Biocompatibility of sol-gel hydroxyapatite-titania composite and bilayer coatings.

Fiche publication

Date publication

mars 2017

Journal

Materials science & engineering. C, Materials for biological applications

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BELJEBBAR Abdelilah , Pr GANGLOFF Sophie , Dr VELARD Frédéric , Dr KERDJOUDJ Halima

Tous les auteurs :
Sidane D, Rammal H, Beljebbar A, Gangloff SC, Chicot D, Velard F, Khireddine H, Montagne A, Kerdjoudj H

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28024634

Résumé

Titania-Hydroxyapatite (TiO2/HAP) reinforced coatings are proposed to enhance the bioactivity and corrosion resistance of 316L stainless steel (316L SS). Herein, spin- and dip-coating sol-gel processes were investigated to construct two kinds of coatings: TiO2/HAP composite and TiO2/HAP bilayer. Physicochemical characterization highlighted the bioactivity response of the TiO2/HAP composite once incubated in physiological conditions for 7days whereas the TiO2/HAP bilayer showed instability and dissolution. Biological analysis revealed a failure in human stem cells adhesion on TiO2/HAP bilayer whereas on TiO2/HAP composite the presence of polygonal shaped cells, possessing good behaviour attested a good biocompatibility of the composite coating. Finally, TiO2/HAP composite with hardness up to 0.6GPa and elastic modulus up to 18GPa, showed an increased corrosion resistance of 316L SS. In conclusion, the user-friendly sol-gel processes led to bioactive TiO2/HAP composite buildup suitable for biomedical applications.