Fiche publication
Date publication
mars 2017
Journal
Journal of the American Chemical Society
Auteurs
Membres identifiés du Cancéropôle Est :
Pr LEHN Jean-Marie
Tous les auteurs :
Schneider S, Licsandru ED, Kocsis I, Gilles A, Dumitru F, Moulin E, Tan J, Lehn JM, Giuseppone N, Barboiu M
Lien Pubmed
Résumé
Triarylamine molecules appended with crown-ethers or carboxylic moieties form self-assembled supramolecular channels within lipid bilayers. Fluorescence assays and voltage clamp studies reveal that the self-assemblies incorporating the crown ethers work as single channels for the selective transport of K(+) or Rb(+). The X-ray crystallographic structures confirm the mutual columnar self-assembly of triarylamines and crown-ethers. The dimensional fit of K(+) cations within the 18-crown-6 leads to a partial dehydration and to the formation of alternating K(+) cation-water wires within the channel. This original type of organization may be regarded as a biomimetic alternative of columnar K(+)-water wires observed for the natural KcsA channel. Supramolecular columnar arrangement was also shown for the triarylamine-carboxylic acid conjugate. In this latter case, stopped-flow light scattering analysis reveals the transport of water across lipid bilayer membranes with a relative water permeability as high as 17 μm s(-1).
Référence
J. Am. Chem. Soc.. 2017 Mar;139(10):3721-3727
