Fiche publication
Date publication
février 2017
Journal
Phytochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie
,
Pr MORJANI Hamid
Tous les auteurs :
Gossan DP, Alabdul Magid A, Yao-Kouassi PA, Ahibo Coffy A, Josse J, Gangloff SC, Morjani H, Voutquenne-Nazabadioko L
Lien Pubmed
Résumé
Six previously undescribed triterpenoid saponins, gouaniaside I-VI, were isolated from the aerial parts of Gouania longipetala Hemsl. (Rhamnaceae), in addition to four known triterpenes. The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D- and 2D-NMR and HR-ESI-MS techniques. The inhibitory activity of isolated compounds against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines was evaluated and jujuboside I exhibited moderate cytotoxicity, with IC50 values of 13.5 and 21.0 μM, respectively. Among the isolated triterpenes, alphitolic acid exhibited moderate antibacterial activity against Staphylococcus aureus, Enterococcus faecalis and Escherichia coli (MICs 32, 64 and 128 μg/mL, respectively).
Mots clés
Anti-Bacterial Agents, chemistry, Antineoplastic Agents, Phytogenic, chemistry, Drug Screening Assays, Antitumor, Enterococcus faecalis, drug effects, Escherichia coli, drug effects, Glycosides, chemistry, HL-60 Cells, Humans, K562 Cells, Microbial Sensitivity Tests, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Components, Aerial, chemistry, Rhamnaceae, chemistry, Saponins, Staphylococcus aureus, drug effects, Triterpenes, chemistry
Référence
Phytochemistry. 2017 Feb;134:71-77
