Agreement between clinicoradiological signs at diagnosis and radiohistological analysis after neoadjuvant chemotherapy of suspected Wilms tumor rupture: Consequences on therapeutic choices.

Fiche publication

Date publication

février 2019

Journal

Pediatric blood & cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BERNIER-CHASTAGNER Valérie , Pr CHASTAGNER Pascal

Tous les auteurs :
Le Rouzic MA, Mansuy L, Galloy MA, Champigneulle J, Bernier V, Chastagner P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30773805

Résumé

According to SIOP criteria, every patient presenting with preoperative Wilms tumor (WT) rupture must receive abdominal radiotherapy. Neoadjuvant chemotherapy reduces tumor volume and is responsible for the development of peritumoral capsule formation, which can mask tumor rupture on histological analysis, while it was clinically or radiologically obvious at diagnosis. Yet, there are no protocol recommendations for this particular presentation.