Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets.

Fiche publication

Date publication

mars 2019

Journal

Gut

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas , Pr PESSAUX Patrick , Dr CROUCHET Emilie , Dr VERRIER Eloi

Tous les auteurs :
Verrier ER, Weiss A, Bach C, Heydmann L, Turon-Lagot V, Kopp A, El Saghire H, Crouchet E, Pessaux P, Garcia T, Pale P, Zeisel MB, Sureau C, Schuster C, Brino L, Baumert TF

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30833451

Résumé

Hepatitis D virus (HDV) is a circular RNA virus coinfecting hepatocytes with hepatitis B virus. Chronic hepatitis D results in severe liver disease and an increased risk of liver cancer. Efficient therapeutic approaches against HDV are absent.