Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity.

Fiche publication

Date publication

mai 2019

Journal

Gut

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas , Dr PFEFFER Sébastien , Dr RAFFELSBERGER Wolfgang

Tous les auteurs :
Herzog K, Bandiera S, Pernot S, Fauvelle C, Jühling F, Weiss A, Bull A, Durand SC, Chane-Woon-Ming B, Pfeffer S, Mercey M, Lerat H, Meunier JC, Raffelsberger W, Brino L, Baumert TF, Zeisel MB

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31076402

Résumé

Infection of human hepatocytes by the hepatitis C virus (HCV) is a multistep process involving both viral and host factors. microRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Given that miRNAs were indicated to regulate between 30% and 75% of all human genes, we aimed to investigate the functional and regulatory role of miRNAs for the HCV life cycle.