Activation of P-TEFb by RBM7: To Live or Let Die.

Date publication

avril 2019

Journal

Molecular cell

Auteurs

Membres identifiés du Cancéropôle Est :
Dr COIN Frédéric , Dr LE MAY Nicolas

Tous les auteurs :
Le May N, Coin F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31002802

Résumé

In this issue of Molecular Cell, Bugai et al. (2019) unveil that a key step of the pro-survival cellular response to a genotoxic attack is the activation of P-TEFb by RBM7. This crucial step triggers RNA polymerase II release from promoter-proximal pausing and expression of DNA damage response genes.

Référence

Mol. Cell. 2019 Apr 18;74(2):223-224