Amyloid PETs are commonly negative in suspected Alzheimer's disease with an increase in CSF phosphorylated-tau protein concentration but an Aβ42 concentration in the very high range: a prospective study.

Fiche publication

Date publication

avril 2019

Journal

Journal of neurology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles , Pr MARIE Pierre-Yves , Pr VERGER Antoine

Tous les auteurs :
Manca C, Rivasseau Jonveaux T, Roch V, Marie PY, Karcher G, Lamiral Z, Malaplate C, Verger A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30963253

Résumé

Atypical cerebrospinal fluid (CSF) patterns, involving an increase in the concentration of phosphorylated-tau (P-tau) proteins but normal amyloid-β concentration, are not uncommon in patients with mild neurocognitive disorders and suspected Alzheimer's disease (AD). In these conditions, however, AD diagnosis may be ruled out in the absence of any amyloid deposition at positron-emission tomography (PET). This pilot cross-sectional study was aimed to determine whether this negativity of amyloid PET can be predicted by CSF profiles in such patients.