Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study.

Date publication

avril 2019

Journal

Clinical nutrition (Edinburgh, Scotland)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr HILLON Patrick

Tous les auteurs :
Mouillot T, Beylot M, Drai J, Hillon P, Gelas P, Lauverjat M, Brondel L, Chambrier C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31000340

Résumé

Short bowel syndrome patients (SBS) receiving parenteral nutrition (PN) often have dyslipidaemia and can develop intestinal failure-associated liver disease (IFALD). These patients demonstrate increased cholesterol synthesis and hepatic lipogenesis. These lipid disturbances may be due to a decreased concentration of the bile acid pool or malabsorption. The aim of this pilot study was to evaluate the effect of bile acid administration on lipid synthesis in patients with SBS.

Mots clés

Intestinal failure-associated liver disease, Lipid metabolism, Parenteral nutrition, Short bowel syndrome, Ursodeoxycholic acid

Référence

Clin Nutr. 2019 Apr 2;: