Appropriateness of pancreatic resection in high-risk individuals for familial pancreatic ductal adenocarcinoma: a patient-level meta-analysis and proposition of the Beaujon score.

Date publication

avril 2019

Journal

United European gastroenterology journal

Auteurs

Membres identifiés du Cancéropôle Est :
Dr VERNEREY Dewi

Tous les auteurs :
de Mestier L, Muller M, Cros J, Vullierme MP, Vernerey D, Maire F, Dokmak S, Rebours V, Sauvanet A, Lévy P, Hammel P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31019704

Résumé

About 5% of pancreatic ductal adenocarcinomas are inherited due to a deleterious germline mutation detected in 20% or fewer families. Pancreatic screening in high-risk individuals is proposed to allow early surgical treatment of (pre)malignant lesions. The outcomes of pancreatic surgery in high-risk individuals have never been correctly explored.

Mots clés

Familial pancreatic carcinoma, cancer screening, hereditary neoplastic syndromes, pancreatic neoplasm, pancreatic surgery

Référence

United European Gastroenterol J. 2019 Apr;7(3):358-368