Role of RXRbeta in platelet function and arterial thrombosis.

Date publication

juin 2019

Journal

Journal of thrombosis and haemostasis : JTH

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CHAMBON Pierre

Tous les auteurs :
Lüsebrink E, Warm V, Pircher J, Ehrlich A, Zhang Z, Strecker J, Chambon P, Massberg S, Schulz C, Petzold T

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31172692

Résumé

Retinoid X receptors (RXR) are a family of nuclear receptors which play critical roles in the regulation of numerous fundamental biological processes including cell proliferation, differentiation and death. Earlier studies suggested that treatment with RXR agonists attenuate platelet activation in men and mice, however, the underlying molecular mechanisms have remained insufficiently understood. To further elaborate on this issue, we characterized megakaryocyte and platelet specific RXR knockout mice to study platelet function in vitro and arterial thrombosis in vivo.

Mots clés

RXR , Nuclear receptor, platelet function, retinoids, thrombosis

Référence

J. Thromb. Haemost.. 2019 Jun 7;: