Fiche publication
Date publication
juin 2019
Journal
European journal of nuclear medicine and molecular imaging
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DENAT Franck
,
Dr GONCALVES Victor
Tous les auteurs :
Raavé R, Sandker G, Adumeau P, Jacobsen CB, Mangin F, Meyer M, Moreau M, Bernhard C, Da Costa L, Dubois A, Goncalves V, Gustafsson M, Rijpkema M, Boerman O, Chambron JC, Heskamp S, Denat F
Lien Pubmed
Résumé
Currently, the most commonly used chelator for labelling antibodies with Zr for immunoPET is desferrioxamine B (DFO). However, preclinical studies have shown that the limited in vivo stability of the Zr-DFO complex results in release of Zr, which accumulates in mineral bone. Here we report a novel chelator DFOcyclo*, a preorganized extended DFO derivative that enables octacoordination of the Zr radiometal. The aim was to compare the in vitro and in vivo stability of [Zr]Zr-DFOcyclo*, [Zr]Zr-DFO* and [Zr]Zr-DFO.
Mots clés
89Zr, DFO, DFO*, DFOcyclo*, Monoclonal antibodies, immunoPET
Référence
Eur. J. Nucl. Med. Mol. Imaging. 2019 Jun 3;:
