Altered thymic CD4 T-cell recovery after allogeneic hematopoietic stem cell transplantation is critical for nocardiosis.

Date publication

juin 2019

Journal

Current research in translational medicine

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BERCEANU Ana , Pr DECONINCK Eric , Dr FERRAND Christophe , Dr LAROSA Fabrice , Pr SEILLES Estelle , Dr DAGUINDAU Etienne , Dr POUTHIER Fabienne

Tous les auteurs :
Roussel X, Daguindau E, Berceanu A, Desbrosses Y, Saas P, Ferrand C, Seilles E, Pouthier F, Deconinck E, Larosa F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31164285

Résumé

Nocardia affects immunocompromised human host exhibiting an altered cell-mediated immunity. Infectious risk after allogeneic hematopoietic cell transplantation (AHCT) is significantly correlated to the recovery status of donor-derived immune system, especially CD4 T-cells reconstitution and thymopoiesis. The purpose of this paper is to highlight a lack of cell-mediated immunity recovery for patients presenting a nocardiosis compared to a control cohort.

Mots clés

Allogeneic hematopoietic stem cell transplant, Immune recovery, Nocardia, Opportunistic infection, Thymic CD4(+)T-cell

Référence

Curr Res Transl Med. 2019 Jun 1;: