Fiche publication
Date publication
février 2019
Journal
The Journal of antimicrobial chemotherapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier
,
Pr NERICH Virginie
,
Pr HOCQUET Didier
Tous les auteurs :
Meunier A, Nerich V, Fagnoni-Legat C, Richard M, Mazel D, Adotevi O, Bertrand X, Hocquet D
Lien Pubmed
Résumé
Infections with antibiotic-resistant pathogens in cancer patients are a leading cause of mortality. Cancer patients are treated with compounds that can damage bacterial DNA, potentially triggering the SOS response, which in turn enhances the bacterial mutation rate. Antibiotic resistance readily occurs after mutation of bacterial core genes. Thus, we tested whether cancer chemotherapy drugs enhance the emergence of resistant mutants in commensal bacteria.
Référence
J. Antimicrob. Chemother.. 2019 Feb 20;:
