Fiche publication
Date publication
avril 2018
Journal
Nature cell biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MENDOZA Manuel
Tous les auteurs :
Kumar A, Sharma P, Gomar-Alba M, Shcheprova Z, Daulny A, Sanmartín T, Matucci I, Funaya C, Beato M, Mendoza M
Lien Pubmed
Résumé
The acquisition of cellular identity is coupled to changes in the nuclear periphery and nuclear pore complexes (NPCs). Whether and how these changes determine cell fate remain unclear. We have uncovered a mechanism that regulates NPC acetylation to direct cell fate after asymmetric division in budding yeast. The lysine deacetylase Hos3 associates specifically with daughter cell NPCs during mitosis to delay cell cycle entry (Start). Hos3-dependent deacetylation of nuclear basket and central channel nucleoporins establishes daughter-cell-specific nuclear accumulation of the transcriptional repressor Whi5 during anaphase and perinuclear silencing of the G1/S cyclin gene CLN2 in the following G1 phase. Hos3-dependent coordination of both events restrains Start in daughter, but not in mother, cells. We propose that deacetylation modulates transport-dependent and transport-independent functions of NPCs, leading to differential cell cycle progression in mother and daughter cells. Similar mechanisms might regulate NPC functions in specific cell types and/or cell cycle stages in multicellular organisms.
Référence
Nat. Cell Biol.. 2018 Apr;20(4):432-442
