Fiche publication
Date publication
juillet 2011
Journal
Haematologica
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CORNILLET-LEFEBVRE Pascale
,
Pr DELMER Alain
Tous les auteurs :
Kosmider O, Delabesse E, de Mas VM, Cornillet-Lefebvre P, Blanchet O, Delmer A, Recher C, Raynaud S, Bouscary D, Viguié F, Lacombe C, Bernard OA, Ifrah N, Dreyfus F, Fontenay M,
Lien Pubmed
Résumé
Ten-eleven translocation 2 (TET2) mutations have been involved in myeloid malignancies. This retrospective study aims at evaluating the frequency and impact of TET2 mutations in 247 secondary acute myeloid leukemia cases referred to as myelodysplasia-related changes (n=201) or therapy-related (n=46) leukemias. Mutation of at least one copy of the TET2 gene was detected in 49 of 247 (19.8%) patients who presented with older age, higher hemoglobin level, higher neutrophil and monocyte counts, and lower platelet count. TET2 mutations were significantly less frequent in therapy-related (8.7%) than myelodysplasia-related changes (22.3%; P=0.035) leukemias and strongly associated with normal karyotype (P<0.001). TET2 mutations did not significantly associate with NPM1, FLT3-ITD or FLT3-D835, WT1, or N- or K-RAS mutations. Complete remission was achieved in 57% of evaluable patients who had received intensive chemotherapy. In this group, TET2 mutations did not influence the complete remission rate or overall survival.
Mots clés
Aged, Aged, 80 and over, DNA-Binding Proteins, genetics, Female, France, Humans, Karyotyping, Leukemia, Myeloid, Acute, genetics, Male, Middle Aged, Mutation, genetics, Neoplasms, Second Primary, genetics, Proto-Oncogene Proteins, genetics, Retrospective Studies, Survival Analysis, WT1 Proteins, genetics
Référence
Haematologica. 2011 Jul;96(7):1059-63
