The ideal small arterial substitute: Role of cell seeding and tissue engineering.

Date publication

janvier 2007

Journal

Clinical hemorheology and microcirculation

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MENU Patrick , Pr BOURA Cédric , Dr KERDJOUDJ Halima

Tous les auteurs :
Kerdjoudj H, Moby V, Berthelemy N, Gentils M, Boura C, Bordenave L, Stoltz JF, Menu P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/17641399

Résumé

Although autogenous vessels are useful in surgery, often patients cannot furnish suitable vessels. If there are not available, two possible alternatives for vessel replacements are to use vascular synthetic prostheses such as Dacron((R)) and polytetrafluoroethylene (PTFE) or cryopreserved allografts. However, their success has been limited to replace small-diameter (<6 mm) arterial vessel because of their high thrombogenicity and compliance mismatch. On account of a clear clinical need for a functional arterial substitute, tissue engineering techniques have been developed. This review encompasses the use of mature endothelial, endothelial progenitor and bone marrow cells combined with natural or synthetic scaffolds whose surface has been modified with multiple origin matrices.

Mots clés

Blood Vessel Prosthesis, Bone Marrow Cells, cytology, Cell Culture Techniques, Endothelial Cells, cytology, Humans, Polymers, therapeutic use, Stem Cells, cytology, Tissue Engineering, methods, Transplantation, Autologous

Référence

Clin. Hemorheol. Microcirc.. 2007 ;37(1-2):89-98