Design and evaluation of histidine-rich amphipathic peptides for siRNA delivery.

Date publication

juillet 2010

Journal

Pharmaceutical research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BECHINGER Burkhard , Dr KICHLER Antoine

Tous les auteurs :
Langlet-Bertin B, Leborgne C, Scherman D, Bechinger B, Mason AJ, Kichler A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/20393870

Résumé

Short linear peptides have a high potential for delivering various drugs with therapeutic potential, including nucleic acids. Recently, we have shown that the cationic amphipathic histidine-rich peptide LAH4 (KKALLALALHHLAHLALHLALALKKA) possesses high plasmid DNA delivery capacities. Since such peptides are thought to efficiently disrupt endosomal membranes, we have tested their ability to deliver small interfering RNA (siRNA) into mammalian cells.

Mots clés

Amino Acid Sequence, Cell Line, Drug Delivery Systems, Drug Design, Histidine, chemistry, Humans, Molecular Sequence Data, Peptides, administration & dosage, RNA, Small Interfering, administration & dosage

Référence

Pharm. Res.. 2010 Jul;27(7):1426-36