Dendron based antifouling, MRI and magnetic hyperthermia properties of different shaped iron oxide nanoparticles.

Fiche publication

Date publication

juin 2019

Journal

Nanotechnology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BEGIN-COLIN Sylvie , Dr BOOS Anne , Dr FELDER-FLESCH Delphine , Dr MERTZ Damien

Tous les auteurs :
Cotin G, Blanco-Andujar C, Nguyen DV, Affolter-Zbaraszczuk C, Boutry S, Boos A, Ronot P, Uring B, Choquet P, Zorn PE, Mertz D, Laurent S, Muller RN, Meyer F, Felder-Flesch D, Begin S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31195384

Résumé

Owing to the great potential of iron oxide nanoparticles (NPs) for nanomedicine, large efforts are made to better control their magnetic properties and especially their magnetic anisotropy to provide NPs able to combine imaging by MRI and therapy by magnetic hyperthermia. In that context, the design of anisotropic NPs appears as a very promising and efficient strategy. Furthermore, their bioactive coating remains also a challenge as it should provide colloidal stability, biocompatibility, furtivity along with good water diffusion for MRI. By taking advantage of our controlled synthesis method of iron oxide NPs with different shapes (cubic, spherical, octopod and nanoplate), we demonstrate here that the dendron coating, shown previously very suitable for 10 nm sized iron oxide, provided also very good colloidal, MRI and antifouling properties to the anisotropic shaped NPs. These antifouling properties, demonstrated through several experiments and characterizations, are very promising to achieve specific targeting of disease tissues without affecting healthy organs. On the other hand, the magnetic hyperthermia properties were shown to depend on the saturation magnetization and the ability of NPs to self-align, confirming the need of a balance between crystalline and dipolar magnetic anisotropies.