Fiche publication
Date publication
mars 2019
Journal
Clinical microbiology reviews
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VUITTON Lucine
Tous les auteurs :
Wen H, Vuitton L, Tuxun T, Li J, Vuitton DA, Zhang W, McManus DP
Lien Pubmed
Résumé
Echinococcosis is a zoonosis caused by cestodes of the genus (family Taeniidae). This serious and near-cosmopolitan disease continues to be a significant public health issue, with western China being the area of highest endemicity for both the cystic (CE) and alveolar (AE) forms of echinococcosis. Considerable advances have been made in the 21st century on the genetics, genomics, and molecular epidemiology of the causative parasites, on diagnostic tools, and on treatment techniques and control strategies, including the development and deployment of vaccines. In terms of surgery, new procedures have superseded traditional techniques, and total cystectomy in CE, resection with autotransplantation in AE, and percutaneous and perendoscopic procedures in both diseases have improved treatment efficacy and the quality of life of patients. In this review, we summarize recent progress on the biology, epidemiology, diagnosis, management, control, and prevention of CE and AE. Currently there is no alternative drug to albendazole to treat echinococcosis, and new compounds are required urgently. Recently acquired genomic and proteomic information can provide a platform for improving diagnosis and for finding new drug and vaccine targets, with direct impact in the future on the control of echinococcosis, which continues to be a global challenge.
Mots clés
Echinococcus, Echinococcus granulosus, Echinococcus multilocularis, alveolar echinococcosis, cystic echinococcosis, echinococcosis, genetic epidemiology, genome, strains/genotypes, transcriptome, zoonosis
Référence
Clin. Microbiol. Rev.. 2019 03 20;32(2):
