Fiche publication
Date publication
janvier 2019
Journal
Frontiers in cellular neuroscience
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VITALE Nicolas
Tous les auteurs :
Tanguy E, Wang Q, Moine H, Vitale N
Lien Pubmed
Résumé
Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a key building block of phospholipid synthesis and a major lipid second messenger conveying signaling information. The latter is thought to largely occur through the ability of PA to recruit and/or activate specific proteins in restricted compartments and within those only at defined submembrane areas. Furthermore, with its cone-shaped geometry PA locally changes membrane topology and may thus be a key player in membrane trafficking events, especially in membrane fusion and fission steps, where lipid remodeling is believed to be crucial. These pleiotropic cellular functions of PA, including phospholipid synthesis and homeostasis together with important signaling activity, imply that perturbations of PA metabolism could lead to serious pathological conditions. In this mini-review article, after outlining the main cellular functions of PA, we highlight the different neurological diseases that could, at least in part, be attributed to an alteration in PA synthesis and/or catabolism.
Mots clés
lipid signaling, neuron, neuropathology, phosphatidic acid, phospholipase D
Référence
Front Cell Neurosci. 2019 ;13:2
