Fiche publication
Date publication
décembre 2018
Journal
Journal of lipid research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VITALE Nicolas
,
Dr PFRIEGER Frank
Tous les auteurs :
Pfrieger FW, Vitale N
Lien Pubmed
Résumé
Eukaryotic cells employ distinct means to release specific signals and material. Research within the last decade has identified different types of membrane-enclosed structures collectively called extracellular vesicles (EVs) as one of them. EVs fall into two categories depending on their subcellular origin. Exosomes are generated within the endosomal system and reach the extracellular space upon fusion of multivesicular bodies. Microvesicles or microparticles are generated by shedding of the plasma membrane. Sterols are essential components of eukaryotic membranes and serve as precursors or cofactors of numerous signaling molecules; their content and subcellular distribution are tightly controlled. The prominent roles of sterols in cells raise the question of whether and how these components impact EVs. In this review, we compile evidence for cholesterol accumulation in EVs and discuss its possible contribution to their biogenesis, release, and uptake. We also consider potential implications of EVs in cellular sterol homeostasis and in cholesterol-related diseases.
Mots clés
atherosclerosis, cellular cholesterol, cholesterol/efflux, diseases/dyslipidemias, endosome, macrophages/monocytes, multivesicular bodies, platelets
Référence
J. Lipid Res.. 2018 12;59(12):2255-2261
