Docosahexaenoic acid, but not eicosapentaenoic acid, improves septic shock-induced arterial dysfunction in rats.

Date publication

janvier 2017

Journal

PloS one

Auteurs

Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie , Dr AUGER Cyril

Tous les auteurs :
Boivin A, Burban M, Clere-Jehl R, Le Borgne P, Merdji H, Auger C, Schini-Kerth V, Meziani F, Helms J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29261735

Résumé

Long chain n-3 fatty acid supplementation may modulate septic shock-induced host response to pathogen-induced sepsis. The composition of lipid emulsions for parenteral nutrition however remains a real challenge in intensive care, depending on their fatty acid content. Because they have not been assessed yet, we aimed at determining the respective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) during septic shock-induced vascular dysfunction.

Mots clés

Animals, Arteries, pathology, Docosahexaenoic Acids, therapeutic use, Eicosapentaenoic Acid, therapeutic use, Epoprostenol, biosynthesis, Male, Nitric Oxide, biosynthesis, Norepinephrine, administration & dosage, Oxidative Stress, Rats, Rats, Wistar, Shock, Septic, complications, Vascular Diseases, drug therapy

Référence

PLoS ONE. 2017 ;12(12):e0189658