Sporadic colorectal cancers with defective mismatch repair display a number of specific morphological characteristics: relationship between the expression of hMLH1 and hMSH2 proteins and clinicopathological features of 273 adenocarcinomas.

Date publication

juillet 2003

Journal

Histopathology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BOUVIER Anne-Marie , Dr CHAPUSOT Caroline

Tous les auteurs :
Chapusot C, Martin L, Mungra N, Rageot D, Bouvier AM, Bonithon Kopp C, Ponnelle T, Faivre J, Piard F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/12823711

Résumé

The aim of this study was to assess the independent value of pathological criteria in the diagnosis of mismatch repair (MMR)-defective sporadic colorectal cancers.

Mots clés

Adaptor Proteins, Signal Transducing, Adenocarcinoma, genetics, Adult, Aged, Aged, 80 and over, Base Pair Mismatch, Biomarkers, Tumor, metabolism, Carrier Proteins, Colorectal Neoplasms, genetics, DNA, Neoplasm, analysis, DNA-Binding Proteins, Female, Humans, Immunoenzyme Techniques, Male, Microsatellite Repeats, Middle Aged, Mucins, metabolism, MutL Protein Homolog 1, MutS Homolog 2 Protein, Neoplasm Proteins, genetics, Neoplasm Staging, Nuclear Proteins, Proto-Oncogene Proteins, genetics, Retrospective Studies, Stromal Cells, metabolism

Référence

Histopathology. 2003 Jul;43(1):40-7