Prospects of in vivo singlet oxygen luminescence monitoring: Kinetics at different locations on living mice.

Date publication

juin 2016

Journal

Photodiagnosis and photodynamic therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina , Dr LASSALLE Henri-Pierre

Tous les auteurs :
Pfitzner M, Schlothauer JC, Bastien E, Hackbarth S, Bezdetnaya L, Lassalle HP, Röder B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26987416

Résumé

Singlet oxygen observation is considered a valuable tool to assess and optimize PDT treatment. In complex systems, such as tumors in vivo, only the direct, time-resolved singlet oxygen luminescence detection can give reliable information about generation and interaction of singlet oxygen. Up to now, evaluation of kinetics was not possible due to insufficient signal-to-noise ratio. Here we present high signal-to-noise ratio singlet oxygen luminescence kinetics obtained in mouse tumor model under PDT relevant conditions.

Mots clés

Administration, Intravenous, Administration, Topical, Animals, Kinetics, Luminescent Measurements, Mice, Mice, Nude, Models, Animal, Photochemotherapy, Photosensitizing Agents, administration & dosage, Signal-To-Noise Ratio, Singlet Oxygen, analysis

Référence

Photodiagnosis Photodyn Ther. 2016 Jun;14:204-10