Fiche publication
Date publication
juillet 2016
Journal
Gut
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ALPY Fabien
,
Dr DE ARCANGELIS Adèle
,
Pr LAQUERRIERE Patrice
,
Dr LEFEBVRE Olivier
Tous les auteurs :
De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, Méchine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E
Lien Pubmed
Résumé
Epidemiological and clinical data indicate that patients suffering from IBD with long-standing colitis display a higher risk to develop colorectal high-grade dysplasia. Whereas carcinoma invasion and metastasis rely on basement membrane (BM) disruption, experimental evidence is lacking regarding the potential contribution of epithelial cell/BM anchorage on inflammation onset and subsequent neoplastic transformation of inflammatory lesions. Herein, we analyse the role of the α6β4 integrin receptor found in hemidesmosomes that attach intestinal epithelial cells (IECs) to the laminin-containing BM.
Référence
Gut. 2016 Jul;:
