Fiche publication
Date publication
juillet 2019
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BELLEMIN-LAPONNAZ Stéphane
Tous les auteurs :
Achard T, Egly J, Sigrist M, Maisse-François A, Bellemin-Laponnaz S
Lien Pubmed
Résumé
A dehydrogenation of primary amine to give the corresponding nitrile under oxidant- and base-free conditions catalysed by simple [Ru(p-cym)Cl2]2 with no extra ligand is reported. The system is highly selective for alkyl amine whereas benzylamine derivatives gave the nitrile product together with the imine in ratio ranging from 14:1 to 4:1 depending on the substrate. Preliminary mechanistic investigations have been performed to identify the key factors that govern the selectivity.
Mots clés
dehydrogenation nitrile syntesis acceptorless dehydrogenation ruthenium homogenous catalysis
Référence
Chemistry. 2019 Jul 9;:
