Fiche publication
Date publication
janvier 2015
Journal
Journal of Alzheimer's disease : JAD
Auteurs
Membres identifiés du Cancéropôle Est :
Pr RAMONT Laurent
,
Dr OUDART Jean-Baptiste
Tous les auteurs :
Salza R, Oudart JB, Ramont L, Maquart FX, Bakchine S, Thoannès H, Ricard-Blum S
Lien Pubmed
Résumé
The aim of this study was to measure the level of endostatin, a fragment of collagen XVIII that accumulates in the brain of patients with Alzheimer's disease (AD), in the cerebrospinal fluids (CSF) of patients with neurodegenerative diseases. The concentrations of total protein, endostatin, amyloid-β1-42 peptide, tau, and hyperphosphorylated tau proteins were measured by enzyme-linked immunosorbent assay in CSF of patients with AD (n = 57), behavioral frontotemporal dementia (bvFTD, n = 22), non AD and non FTD dementia (nAD/nFTD, n = 84), and 45 subjects without neurodegenerative diseases. The statistical significance of the results was assessed by Mann-Whitney and Kruskal and Wallis tests, and by ROC analysis. The concentration of endostatin in CSF was higher than the levels of the three markers of AD both in control subjects and in patients with neurodegenerative diseases. The endostatin/amyloid-β1-42 ratio was significantly increased in patients with AD (257%, p < 0.0001) and nAD/nFTD (140%, p < 0.0001) compared to controls. The endostatin/tau protein ratio was significantly decreased in patients with AD (-49%, p < 0.0001) but was increased in bvFTD patients (89%, p < 0.0001) compared to controls. In the same way, the endostatin/hyperphosphorylated tau protein ratio was decreased in patients with AD (-21%, p = 0.0002) but increased in patients with bvFTD (81%, p = 0.0026), compared to controls. The measurement of endostatin in CSF and the calculation of its ratio relative to well-established AD markers improve the diagnosis of bvFTD patients and the discrimination of patients with AD from those with bvFTD and nAD/nFTD.
Mots clés
Aged, Aged, 80 and over, Alzheimer Disease, cerebrospinal fluid, Amyloid beta-Peptides, cerebrospinal fluid, Endostatins, cerebrospinal fluid, Female, Frontotemporal Dementia, cerebrospinal fluid, Humans, Male, Middle Aged, Peptide Fragments, cerebrospinal fluid, Phosphorylation, Psychiatric Status Rating Scales, ROC Curve, tau Proteins, cerebrospinal fluid
Référence
J. Alzheimers Dis.. 2015 ;44(4):1253-61
