Fiche publication
Date publication
juillet 2015
Journal
Transfusion
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PERRUCHE Sylvain
Tous les auteurs :
Vallion R, Bonnefoy F, Daoui A, Vieille L, Tiberghien P, Saas P, Perruche S
Lien Pubmed
Résumé
Red blood cell (RBC) alloimmunization is a major immunologic risk of transfusion. However, RBC storage facilitates white blood cell (WBC) apoptosis and apoptotic cells have immunomodulatory properties. We investigated the behavior of WBCs, and apoptosis in particular, in RBC units during storage and then studied the impact of WBC apoptosis on the modulation of posttransfusion alloimmunization in RBC products stored short term.
Mots clés
Animals, Apoptosis, immunology, Blood Preservation, Erythrocyte Transfusion, Erythrocytes, immunology, Immunomodulation, Leukocytes, immunology, Mice, Mice, Inbred BALB C, Transforming Growth Factor beta, blood
Référence
Transfusion. 2015 Jul;55(7):1721-35
